| Identification | Back Directory | [Name]
N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-5,7-DIPHENYLPYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXAMIDE | [CAS]
326923-09-5 | [Synonyms]
JNJ-9350
TOSLAB 794812
N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-5,7-DIPHENYLPYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXAMIDE
Pyrazolo[1,5-a]pyrimidine-2-carboxamide, N-[3-(1H-imidazol-1-yl)propyl]-5,7-diphenyl- | [Molecular Formula]
C25H22N6O | [MDL Number]
MFCD01050984 | [MOL File]
326923-09-5.mol | [Molecular Weight]
422.48 |
| Chemical Properties | Back Directory | [density ]
1.28±0.1 g/cm3(Predicted) | [solubility ]
DMSO: Sparingly Soluble: 1-10 mg/ml
Methanol: Slightly Soluble: 0.1-1 mg/ml | [form ]
Solid | [pka]
10.08±0.46(Predicted) | [color ]
White to light brown |
| Hazard Information | Back Directory | [Uses]
JNJ-9350 is an inhibitor of spermine oxidase (SMOX) with an IC50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer[1]. | [in vivo]
1.19 Pharmacokinetic Properties of JNJ-9350 in Mice [1]. | Mice
PO 10 mg/kg | | Clearance (mL/min/kg) (Total/Unbound) | 73/5217 | | Volume of distribution (L/kg) | 1.7 | | Half-life (min) | 16 | | PPB (Mouse) | 98.6% | | Oral F% | 34% | |
| [References]
[1] SMOx PROBE PROPOSAL |
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Specs
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+31 15 251 8111 |
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www.specs.net |
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