| Hazard Information | Back Directory | [Description]
BIO-7662 is a potent and highly selective α4β1 integrin antagonist. | [Uses]
BIO7662 is a specific α4β1 antagonist. BIO7662 can be used to study α4β1 integrin-ligand interactions[1][2]. | [References]
[1] Egger LA, et al. A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence. J Pharmacol Exp Ther. 2003 Sep;306(3):903-13. DOI:10.1124/jpet.102.047704
[2] Chen LL,et al. Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium. J Biol Chem. 2001 Sep 28;276(39):36520-9. DOI:10.1074/jbc.M106216200 |
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