328-79-0

401-99-0

124-41-4

328-79-0

To a solution of 3,5-dinitrobenzotrifluoride (10 g, 42.4 mmol) in anhydrous methanol (100 mL) was slowly added a solution of sodium methanolate (3.43 g, 63.5 mmol) in anhydrous methanol (20 mL). The reaction mixture was heated to reflux for 1 hour and subsequently concentrated by rotary evaporation to remove the methanol solvent. The concentrated residue was diluted with ethyl acetate (80 mL) and water (30 mL) to separate the organic phase. The organic phase was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give 3-nitro-5-(trifluoromethyl)anisole (8.5 g) as a red solid. The product was analyzed by LC-MS (ESI): no [M + H]+ peak was observed; retention time was 1.85 min.