| Identification | Back Directory | [Name]
Ceranib 1 | [CAS]
328076-61-5 | [Synonyms]
Ceranib 1
Ceranib-1,Ceranib1
2(1H)-Quinolinone, 3-[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-
3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone | [Molecular Formula]
C26H21NO3 | [MDL Number]
MFCD01152737 | [MOL File]
328076-61-5.mol | [Molecular Weight]
395.45 |
| Hazard Information | Back Directory | [Uses]
Ceranib1 is a ceramidase inhibitor. Ceranib1 inhibits ceramidase activity toward an exogenous ceramide analog, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. Ceranib1 inhibits the proliferation of ovarian cancer cells[1]. | [Biological Activity]
Ceranib 1 is a ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells. | [storage]
Store at +4°C | [References]
[1] Draper JM, et al. Discovery and evaluation of inhibitors of human ceramidase. Mol Cancer Ther. 2011 Nov;10(11):2052-61. DOI:10.1158/1535-7163.MCT-11-0365 |
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https://www.bocsci.com |
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