| Identification | Back Directory | [Name]
HIF-1alpha/2alpha Inhibitor | [CAS]
329932-55-0 | [Synonyms]
FM19G11
FM 19G11 NEW
FM19G11 >=98% (HPLC)
HIF-1alpha/2alpha Inhibitor
HIF-1α/2α Inhibitor IV, FM19G11
2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate
[2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate
3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester
Benzoic acid, 3-[(2,4-dinitrobenzoyl)amino]-, 2-(4-methylphenyl)-2-oxoethyl ester | [Molecular Formula]
C23H17N3O8 | [MDL Number]
MFCD01174289 | [MOL File]
329932-55-0.mol | [Molecular Weight]
463.4 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥40mg/mL | [form ]
powder | [color ]
off-white to light brown | [InChI]
1S/C23H17N3O8/c1-14-5-7-15(8-6-14)21(27)13-34-23(29)16-3-2-4-17(11-16)24-22(28)19-10-9-18(25(30)31)12-20(19)26(32)33/h2-12H,13H2,1H3,(H,24,28) | [InChIKey]
XVUOIWIIQVGWAJ-UHFFFAOYSA-N | [SMILES]
Cc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)c3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c2 |
| Hazard Information | Back Directory | [Uses]
FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):
- to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
- to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
- to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line
| [Definition]
ChEBI: 3-[[(2,4-dinitrophenyl)-oxomethyl]amino]benzoic acid [2-(4-methylphenyl)-2-oxoethyl] ester is a member of benzamides. | [Biochem/physiol Actions]
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models. | [in vivo]
FM19G11 ( intramedullary injection; 1-8 weeks) improves locomotion in severe spinal cord injury (SCI)[3].
FM19G11 ( intramedullary injection; 8 weeks) induces the expression of GAP43, an axon growth marker, and RIP, a marker for myelinated oligodendrocytes at the injury[3]. | [storage]
Store at 4°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|