| Identification | More | [Name]
4-Bromo-1-butanol | [CAS]
33036-62-3 | [Synonyms]
4-BROMO-1-BUTANOL
TETRAMETHYLENE BROMOHYDRIN
4-bromobutan-1-ol
4-Bromobutanol
1-BROMO-4-BUTANOL
4-Bromo-1-butenol
4-Bromo-1-butanol (contains varying amounts of Tetrahydrofuran)
4-BROMO-1-BUTANOL, 85+% | [EINECS(EC#)]
251-355-5 | [Molecular Formula]
C4H9BrO | [MDL Number]
MFCD00015387 | [Molecular Weight]
153.02 | [MOL File]
33036-62-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless to brown liquid | [Boiling point ]
56-58 | [density ]
1.68 | [Fp ]
7 °C | [refractive index ]
1.5035 | [storage temp. ]
−20°C
| [solubility ]
Chloroform (Sparingly), Methanol (Sparingly) | [form ]
Liquid | [pka]
14.98±0.10(Predicted) | [color ]
Yellow | [Water Solubility ]
insoluble | [Sensitive ]
Moisture & Light Sensitive | [BRN ]
1839430 | [InChI]
InChI=1S/C4H9BrO/c5-3-1-2-4-6/h6H,1-4H2 | [InChIKey]
SIJLYRDVTMMSIP-UHFFFAOYSA-N | [SMILES]
C(O)CCCBr | [CAS DataBase Reference]
33036-62-3(CAS DataBase Reference) | [NIST Chemistry Reference]
1-Butanol, 4-bromo-(33036-62-3) |
| Questions And Answer | Back Directory | [Preparation]
200 kg of tetrahydrofuran and 19 kg (0.07 eq) of concentrated sulfuric acid were added sequentially to a 1000 L reactor. The system temperature was controlled at 2 ± 2 °C. 420 kg (0.9 eq) of 48% hydrobromic acid aqueous solution was slowly added dropwise. After the addition was complete, the temperature was raised to 80 ± 2 °C and maintained for 3 h. After the reaction was completed, the temperature was lowered to 0 ± 2 °C. The pH of the system was adjusted to 7-8 with 23 kg (0.1 eq) of sodium bicarbonate. Extraction was performed, the organic phase was washed, and the mixture was concentrated to obtain 286 kg of the oily product 4-bromo-1-butanol, with a yield of 67.5% and a gas chromatographic purity (GC) of 97.0%. | [Description]
4-Bromo-1-butanol can be prepared by azeotropic distillation of butane-1,4-diol with 47% HBr with a yield of about 65%.1 4-Bromo-1-butanol can be used to prepare 2-(4-bromo-butoxy)-tetrahydro-pyran by reacting with 3,4-dihydro-2H-pyran in the presence of amberlyst 15 and the menstruum hexane.1 It reacts with dihydropyran to prepare tetrahydropyranyl ethers.2
|
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS02,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H225-H315-H319-H335 | [Precautionary statements ]
P210-P302+P352-P305+P351+P338 | [Hazard Codes ]
F,Xi,Xn | [Risk Statements ]
R11:Highly Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 1987 3/PG 2
| [WGK Germany ]
3
| [F ]
8-10 | [Hazard Note ]
Irritant/Flammable | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29055998 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to brown liquid | [Uses]
4-Bromo-1-butanol is used to prepare 2-(4-bromo-butoxy)-tetrahydro-pyran by reacting with 3,4-dihydro-2H-pyran in the presence of amberlyst 15 as a catalyst. It reacts with dihydropyran to prepare tetrahydropyranyl ethers. | [Definition]
ChEBI: 4-Bromo-1-butanol is a primary alcohol. |
|
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J & K SCIENTIFIC LTD.
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Alfa Aesar
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Energy Chemical
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Aemon Chemical
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