| Identification | More | [Name]
1-(2-BROMOETHYL)-4-FLUOROBENZENE | [CAS]
332-42-3 | [Synonyms]
1-(2-BROMOETHYL)-4-FLUOROBENZENE
1-BROMO-2-(4-FLUOROPHENYL)ETHANE
1-FLUORO-4-(2-BROMOETHYL)BENZENE
2-(4-FLUOROPHENYL)ETHYL BROMIDE
4-FLUORO-1-(2-BROMOETHYL)BENZENE
4-FLUOROPHENETHYL BROMIDE
1-(2-Bromoethyl)-4-fluoroBenzene,4-FluorophenethylBromide
1-Bromo-2-(4-fluorophenyl)ethane 97%
1-Bromo-2-(4-fluorophenyl)ethane97%
1-Fluoro-4-(2-bromoethyl)benzene, 4-Fluoro-1-(2-bromoethyl)benzene | [Molecular Formula]
C8H8BrF | [MDL Number]
MFCD03844794 | [Molecular Weight]
203.05 | [MOL File]
332-42-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear slightly yellow liquid | [Boiling point ]
100-104 °C15 mm Hg(lit.) | [density ]
1.4498 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.534(lit.)
| [Fp ]
200 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Liquid or Low Melting Solid | [color ]
Clear colorless to light yellow or white to pale yellow | [CAS DataBase Reference]
332-42-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
R22:Harmful if swallowed.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 3082 9 / PGIII | [WGK Germany ]
2
| [HazardClass ]
9 | [HS Code ]
29039990 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear slightly yellow liquid | [Uses]
An intermediate in the production of protein A mimetics, serotonin antagonists, and other CNS agents | [Synthesis]
Preparative Example 1 Synthesis of 4-fluorophenethyl bromide: Triphenylphosphine (222 g) and N-bromosuccinimide (151 g) were sequentially added to a solution of 4-fluorophenylethanol (100 g) in dichloromethane (1 L) under cooling conditions in an ice bath and the reaction was carried out with continuous stirring for 1 hour. Upon completion of the reaction, the resulting solution was concentrated under reduced pressure and the precipitated crystals were subsequently filtered. The filtrate was further concentrated to afford the target product 4-fluorobromoethylbenzene (133 g) as a colorless oil (yield: 92%). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ (ppm) 3.14 (2H, t, J = 8 Hz), 3.54 (2H, t, J = 8 Hz), 6.98-7.03 (2H, m), 7.15-7.18 (2H, m). | [References]
[1] Journal of Organic Chemistry, 2006, vol. 71, # 18, p. 7035 - 7044
[2] Tetrahedron Asymmetry, 2001, vol. 12, # 4, p. 585 - 596
[3] Patent: US2002/19531, 2002, A1
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 8, p. 2989 - 3002
[5] Patent: EP2508526, 2012, A1. Location in patent: Page/Page column 48 |
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