| Identification | Back Directory | [Name]
Benzamide, N-(4-iodophenyl)-4-(4-morpholinylmethyl)- | [CAS]
333357-56-5 | [Synonyms]
WAY-299838
HIF-1 inhibitor-4
N-(4-Iodophenyl)-4-(morpholinomethyl)benzamide
Benzamide, N-(4-iodophenyl)-4-(4-morpholinylmethyl)- | [Molecular Formula]
C18H19IN2O2 | [MOL File]
333357-56-5.mol | [Molecular Weight]
422.26 |
| Chemical Properties | Back Directory | [Boiling point ]
435.4±45.0 °C(Predicted) | [density ]
1.576±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.90±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1]. | [References]
[1] Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5513-29. DOI:10.1016/j.bmc.2014.07.020 |
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