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333742-63-5

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333742-63-5 Structure

333742-63-5 Structure
IdentificationBack Directory
[Name]

AZ 10397767
[CAS]

333742-63-5
[Synonyms]

AZ 10397767
5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one
Thiazolo[4,5-d]pyrimidin-2(3H)-one, 5-[[(3-chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]-
[Molecular Formula]

C15H14ClFN4O2S2
[MDL Number]

MFCD30729652
[MOL File]

333742-63-5.mol
[Molecular Weight]

400.88
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:40.09(Max Conc. mg/mL);100.01(Max Conc. mM)
Hazard InformationBack Directory
[Uses]

AZ 10397767 is a potent CXCR2 antagonist. CXCR2 is a chemokine receptor found on immune cells and involved with acute and chronic inflammation. CXCR2 inhibitors have therapeutic potential for treating chronic obstructive pulmonary disease and cystic fibrosis.
[in vivo]

AZ10397767 (100 mg/kg; Orally; twice daily; for 22 days) display reduced neutrophil infiltration accompanied with retardation in tumor growth in A549 xenograft tumors[4].
AZ10397767 (compound 30a) has a CL of 4 ml/min/kg in rat[1].

Animal Model:SCID mice with A549 cells[4]
Dosage:100 mg/kg
Administration:Orally; twice daily; for 22 days
Result:Tumors were 36% smaller than their control counterparts.
Significantly (p < 0.01) reduced the number of tumor-infiltrating neutrophils compared to mice receiving vehicle control.
[IC 50]

CXCR2: 1 nM (IC50)
[storage]

Store at -20°C
333742-63-5 suppliers list
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Telephone: 0513-66337626 18051384581
Website: https://www.chemhifuture.com/
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Telephone: 025-85560043 15850508050
Website: http://www.synzest.com
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
Tags:333742-63-5 Related Product Information
333742-63-5 333742-48-6