| Identification | Back Directory | [Name]
3,5-Pyridinedicarbonitrile, 2-amino-6-[(2-hydroxyethyl)thio]-4-(4-hydroxyphenyl)- | [CAS]
333963-57-8 | [Synonyms]
LUF5831
LUF-5831
LUF 5831
3,5-Pyridinedicarbonitrile, 2-amino-6-[(2-hydroxyethyl)thio]-4-(4-hydroxyphenyl)- | [Molecular Formula]
C15H12N4O2S | [MOL File]
333963-57-8.mol | [Molecular Weight]
312.35 |
| Chemical Properties | Back Directory | [Melting point ]
224 °C (decomp)(Solv: dichloromethane (75-09-2); methanol (67-56-1)) | [Boiling point ]
617.0±55.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [pka]
6.67±0.15(Predicted) |
| Hazard Information | Back Directory | [Description]
LUF5831 is a novel adenosine A1 receptor agonist. | [Uses]
LUF5831 is a non-adenosine agonist with an affinity of Ki=18 nM for adenosine A1 receptor[1]. | [References]
[1] Heitman LH, et al., Allosteric modulation, thermodynamics and binding to wild-type and mutant (T277A) adenosine A1 receptors of LUF5831, a novel nonadenosine-like agonist. Br J Pharmacol. 2006 Mar;147(5):533-41. DOI:10.1038/sj.bjp.0706655 |
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