| Identification | Back Directory | [Name]
2-(((1H-Imidazol-2-yl)methyl)thio)-6-amino-4-(4-hydroxyphenyl)pyridine-3,5-dicarbonitrile | [CAS]
333962-91-7 | [Synonyms]
LUF 5834
2-Amino-4-(4-hydroxyphenyl)-6-[(1H-imidazol-2-ylmethyl)thio]-3,5-pyridinecarbonitrile
3,5-Pyridinedicarbonitrile, 2-amino-4-(4-hydroxyphenyl)-6-[(1H-imidazol-2-ylmethyl)thio]-
2-(((1H-Imidazol-2-yl)methyl)thio)-6-amino-4-(4-hydroxyphenyl)pyridine-3,5-dicarbonitrile
2-Amino-4-(4-hydroxy-phenyl)-6-(1H-imidazol-2-ylmethylsulfanyl)-pyridine-3,5-dicarbonitrile | [Molecular Formula]
C17H12N6OS | [MOL File]
333962-91-7.mol | [Molecular Weight]
348.38 |
| Hazard Information | Back Directory | [Uses]
LUF 5834 is a high-efficacy partial agonist with EC50 = 12 nM and 45-fold selectivity over the adenosine A3 receptor but lacking selectivity vs. the A1 and A2A subtypes. | [Biological Activity]
LUF5834 is a potent A2A and A2B adenosine receptor partial agonist with an EC50 value of 12 nM and 45-fold selectivity over the adenosine A3 receptor. | [IC 50]
A2BR: 12 nM (EC50); A2AR: 28 nM (Ki); A1R: 2.6 nM (Ki) | [storage]
Store at -20°C |
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