| Identification | Back Directory | [Name]
Methanone, cyclohexyl[4-[[3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl]- | [CAS]
334668-69-8 | [Synonyms]
CB1R antagonist 1
Methanone, cyclohexyl[4-[[3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl]- | [Molecular Formula]
C18H23F3N2O3S | [MOL File]
334668-69-8.mol | [Molecular Weight]
404.45 |
| Chemical Properties | Back Directory | [Boiling point ]
533.5±60.0 °C(Predicted) | [density ]
1.334±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
-1.12±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC50 value of 4.2 μM and EC50 value of ＞10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity[1]. | [IC 50]
hCB1-R: 4.2 μM (IC50); hCB1-R: 10 μM (EC50) | [References]
[1] Petr Vachal, et al. 1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity. J Med Chem. 2009 Apr 23;52(8):2550-8 DOI:10.1021/jm900063x |
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