| Identification | More | [Name]
L-CYCLOSERINE | [CAS]
339-72-0 | [Synonyms]
H-CYCLOSERINE
L-4-AMINO-3-ISOOXAZOLIDINONE
L-4-AMINO-3-ISOXALOLIDINONE
L-4-AMINO-3-ISOXAZOLIDINONE
L-CYCLOSERINE
S(-)-4-AMINO-3-ISOXAZOLIDINONE
(S)-4-AMINO-3-ISOXAZOLIDONE
(l)-3-isoxazolidinon
(s)-3-isoxazolidinon
Levcycloserine
L-4-aminoisoxazolidin-3-one
(S)-(-)-CYCLOSERINE, 97%
L-CYCLOSERIN
3-Isoxazolidinone, 4-amino-, (4S)-
3-Isoxazolidinone, 4-amino-, (S)-
Cyclo-L-serine
3-Isoxazolidinone,4-amino-,(4S)-(9CI)
(S)-4-Amino-3-isoxazolidone, L-4-Amino-3-isoxazolidinone, L-Cycloserine, L-cycloserine
(4S)-4-Aminoisoxazolidin-3-one
(S)-4-Aminoisoxazolidin-3-one | [EINECS(EC#)]
206-427-0 | [Molecular Formula]
C3H6N2O2 | [MDL Number]
MFCD00064324 | [Molecular Weight]
102.09 | [MOL File]
339-72-0.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE GRANULAR POWDER | [Melting point ]
147 °C | [Boiling point ]
191.38°C (rough estimate) | [density ]
1.278 | [refractive index ]
1.5110 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
H2O: soluble50mg/mg protein | [form ]
White to off-white powder. | [pka]
14.36±0.40(Predicted) | [color ]
White to Off-White | [Water Solubility ]
H2O: 50mg/mg protein | [BRN ]
80799 | [InChI]
InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m0/s1 | [InChIKey]
DYDCUQKUCUHJBH-REOHCLBHSA-N | [SMILES]
N[C@H]1CONC1=O | [CAS DataBase Reference]
339-72-0(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Preparation]
① L-CYCLOSERINE is produced by fermentation, extraction, and refining of actinomycetes. ② L-CYCLOSERINE can be prepared by reacting serine methyl ester hydrochloride with chloroform under the catalysis of phosphorus pentachloride to remove the hydroxyl group, followed by reaction with hydroxylamine in sodium hydroxide solution. |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE GRANULAR POWDER | [Uses]
antibacterial, coccidiostat | [Uses]
L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase. | [Definition]
ChEBI: A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora. | [Biochem/physiol Actions]
L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis. | [Purification Methods]
Purify cycloserine by recrystallisation from aqueous EtOH or MeOH or aqueous NH3/EtOH or isoPrOH. Also recrystallise it from aqueous ammoniacal solution at pH 10.5 (100mg/mL) by diluting with 5 volumes of isopropanol and then adjusting to pH 6 with acetic acid. An aqueous solution, buffered to pH 10 with Na2CO3, can be stored in a refrigerator for 1week without decomposition. UV: max at 226nm (A1cm 1% 4.02). The tartrate salt has m 165-166o (dec), 166-168o (dec), and [] D 24 -41o (c 0.7, H2O). [Stammer et al. J Am Chem Soc 79 3236 1959, UV: Kuehl J Am Chem Soc 77 2344 1955, Beilstein 27 III/IV 5549.] |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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T&W GROUP
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021-61551611 13296011611 |
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www.trustwe.com/ |
| Company Name: |
NCE Biomedical Co.,Ltd.
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
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