| Identification | Back Directory | [Name]
3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone | [CAS]
342808-40-6 | [Synonyms]
EF-24
5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone
3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone
4-Piperidinone, 3,5-bis[(2-fluorophenyl)methylene]-
(3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone
ERK,EF24,Caspase,inhibit,Inhibitor,Extracellular signal regulated kinases | [Molecular Formula]
C19H15F2NO | [MDL Number]
MFCD08560185 | [MOL File]
342808-40-6.mol | [Molecular Weight]
311.33 |
| Hazard Information | Back Directory | [Uses]
3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone is an analog of curcumin that acts as a kinase inhibitor which mediates anticancer properties. | [Biological Activity]
EF-24 is a IKK inhibitor and curcumin analog. EF-24 is more potent and bioavailable than curcuminwith 10-fold greater potency in cell death induction. It is also more efficacious in anti-cancer screens and less toxic than Cisplatin. EF-24 inhibits HIF-1alpha posttranscriptional activity and induces microtubule stabilizationin contrast to Curcumin. EF-24 up-regulates PTEN expression via inhibition of ubiquitination. EF-24 induces cell death through direct inhibition of IkappaB kinase (IKK)resulting in suppression in NFKB activity.''EF-24 is a IKK inhibitor and curcumin analog. EF-24 is more potent and bioavailable than curcuminwith 10-fold greater potency in cell death induction. It is also more efficacious in anti-cancer screens and less toxic than Cisplatin. EF-24 inhibits HIF-1α posttranscriptional activity and induces microtubule stabilizationin contrast to Curcumin. EF-24 up-regulates PTEN expression via inhibition of ubiquitination. EF-24 induces cell | [in vivo]
EF24 (0.4 mg/kg, i.p., a single dose for 6 h) markedly ameliorates the post-hemorrhage morphologic changes and inflammatory cell infiltration, inhibits hemorrhage-induced NF-kB phosphorylation in rat model of hemorrhage[4].
| Animal Model: | Rat model of hemorrhage[4] | | Dosage: | 0.4 mg/kg | | Administration: | i.p., a single dose for 6 h | | Result: | Prevented the hemorrhage-induced increase in myeloperoxidase activity and phospho-NF-kB p65 in hemorrhaged lung tissue. |
| [storage]
Store at -20°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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