| Identification | More | [Name]
2-Bromo-3-methylpyridine | [CAS]
3430-17-9 | [Synonyms]
2-BROMO-3-METHYLPYRIDINE
2-BROMO-3-PICOLINE
2-BROMO-3-METHYLPYRIDINE 98%
2-BROMO-3-METHYLPYRIDINE (2-BROMO-3-PICOLINE)
2-Bromo-3-methylpyridine, 98+% | [EINECS(EC#)]
629-415-0 | [Molecular Formula]
C6H6BrN | [MDL Number]
MFCD00239380 | [Molecular Weight]
172.02 | [MOL File]
3430-17-9.mol |
| Chemical Properties | Back Directory | [Appearance]
clear slightly yellow to light brown liquid | [Boiling point ]
218-219 °C (lit.) | [density ]
1.544 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.568(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Liquid | [pka]
1.08±0.10(Predicted) | [color ]
Clear slightly yellow to light brown | [Specific Gravity]
1.55 | [BRN ]
107896 | [InChI]
InChI=1S/C6H6BrN/c1-5-3-2-4-8-6(5)7/h2-4H,1H3 | [InChIKey]
PZSISEFPCYMBDL-UHFFFAOYSA-N | [SMILES]
C1(Br)=NC=CC=C1C | [CAS DataBase Reference]
3430-17-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Harmful | [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
29333990 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
2-Bromo-3-methylpyridine is a diazido compound with a hydrogen bond. It reacts rapidly with copper chloride to form the coordination complex Cu(diazido)(Cl)2 and an organic product. | [Chemical Properties]
clear slightly yellow to light brown liquid | [Uses]
2-Bromo-3-methylpyridine(3430-17-9) is a halogenated pyridine analogue containing a bromine functional group. The substance is used as a reaction reagent and as a basic structural unit in organic synthesis for the preparation of other heterocyclic compounds.
| [Production Methods]
2-Bromo-3-methylpyridine can be synthesized from 2,4-dibromopyridine by a cross coupling reaction with copper chloride and calcium carbonate in the presence of sodium potassium bicarbonate. | [Synthesis]
A solution of 2,3-dibromopyridine (0.10 M, 3.0 mL) in THF was stirred at T ℃. A solution of n-BuLi (0.40 M, 0.75 mL) in hexane was added dropwise to this solution at a regular pace for 1.0 min. After stirring for 10 min, iodomethane (0.60 M, 1.5 mL) was added dropwise to this mixture at a regular pace for 1.0 min. After stirring at T ℃ for 10 min, a cooling bath was removed. When the reaction mixture reached room temperature and was quenched with H2O, the yields of 2-bromo-3-methylpyridine (2) and 2-bromopyridine (3) and the conversion of 2,3-dibromopyridine (1) was analyzed by GC.
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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