| Identification | Back Directory | [Name]
(E)-2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]thiazolo[3,2-a]benzimidazol-3(2H)-one | [CAS]
347323-96-0 | [Synonyms]
ITX 3
CS-1227
ITX3 >=98% (HPLC)
Trio N-Terminal RhoGEF Domain Inhibitor, ITX3
Trio N-Terminal RhoGEF Domain Inhibitor, ITX3 - CAS 347323-96-0 - Calbiochem
2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-thiazolo[3,2-a]benzimidazol-3(2H)-one
Thiazolo[3,2-a]benzimidazol-3(2H)-one, 2-[(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-
(E)-2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]thiazolo[3,2-a]benzimidazol-3(2H)-one | [Molecular Formula]
C22H17N3OS | [MDL Number]
MFCD02629172 | [MOL File]
347323-96-0.mol | [Molecular Weight]
371.45 |
| Chemical Properties | Back Directory | [Boiling point ]
589.5±60.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: ≥4mg/mL | [form ]
Yellow solid | [pka]
0.17±0.20(Predicted) | [color ]
Light yellow to yellow | [InChI]
1S/C22H17N3OS/c1-14-12-16(15(2)24(14)17-8-4-3-5-9-17)13-20-21(26)25-19-11-7-6-10-18(19)23-22(25)27-20/h3-13H,1-2H3/b20-13+ | [InChIKey]
SJMYMKPBODEZSH-DEDYPNTBSA-N | [SMILES]
Cc1cc(\C=C2\Sc3nc4ccccc4n3C2=O)c(C)n1-c5ccccc5 |
| Hazard Information | Back Directory | [Uses]
ITX3 is a nontoxic inhibitor of TrioN, the N-terminal GEF domain of the multidomain Trio protein. ITX 3 specifically inhibited endogenous TrioN activity. | [Biological Activity]
ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs. |
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