348-59-4

95-82-9

348-59-4

General procedure for the synthesis of 2,5-dichlorofluorobenzene from 2,5-dichloroaniline: 1. Continuous diazotization step: material A (50 mL aqueous solution containing 2,5-dichloroaniline (100 mmol), fluoboric acid (120 mmol) and hydrochloric acid (180 mmol)) was pumped through a T-fitting into a reaction tube at a flow rate of 4 mL/min at 25°C with material B (50 mL aqueous solution containing sodium nitrite (105 mmol)), the mixture flowed through the outlet and collected in a cooling vessel. Vigorous stirring was maintained. The slurry was cooled to -5 °C and then diafiltrated. The solid was washed with methanol and subsequently dried under vacuum to give 2,5-dichlorobenzenediazonium tetrafluoroborate. 2. Continuous fluorination step: a slurry of 2,5-dichlorobenzenediazonium tetrafluoroborate prepared above in 300 mL of co-solvent was introduced continuously into a reaction tube at a flow rate of 4 mL/min. The mixture was kept at the set temperature for 1 min and subsequently cooled in the tandem tube. The collected liquid was washed with aqueous NaOH and water to give an almost colorless liquid of 2,5-dichlorofluorobenzene.