| Identification | Back Directory | [Name]
Z-GLY-GLY-PHE-CHLOROMETHYLKETONE | [CAS]
35172-59-9 | [Synonyms]
Z-GLY-GLY-PHE-CMK
Z-GLY-GLY-PHE-CHLOROMETHYLKETONE
N-cbz-gly-gly-phe chloromethyl ketone
N-carbobenzyloxy-Gly-Gly-Phe chloromethyl ketone
benzyl N-[2-[[2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate | [Molecular Formula]
C22H24ClN3O5 | [MDL Number]
MFCD00057806 | [MOL File]
35172-59-9.mol | [Molecular Weight]
445.9 |
| Chemical Properties | Back Directory | [Boiling point ]
751.7±60.0 °C(Predicted) | [density ]
1.281±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [pka]
11.03±0.46(Predicted) | [Sequence]
{Cbz}-Gly-Gly-Phe-{CMK} |
| Hazard Information | Back Directory | [Uses]
Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC50 value of 125 μM[1]. | [References]
[1] Moreira W, et, al. Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome. Front Microbiol. 2017 Apr 27;8:746. DOI:10.3389/fmicb.2017.00746 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|