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35172-59-9 Structure

Identification	Back Directory
[Name] Z-GLY-GLY-PHE-CHLOROMETHYLKETONE
[CAS] 35172-59-9
[Synonyms] Z-GLY-GLY-PHE-CMK Z-GLY-GLY-PHE-CHLOROMETHYLKETONE N-cbz-gly-gly-phe chloromethyl ketone N-carbobenzyloxy-Gly-Gly-Phe chloromethyl ketone benzyl N-[2-[[2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate
[Molecular Formula] C22H24ClN3O5
[MDL Number] MFCD00057806
[MOL File] 35172-59-9.mol
[Molecular Weight] 445.9

Chemical Properties	Back Directory
[Boiling point ] 751.7±60.0 °C(Predicted)
[density ] 1.281±0.06 g/cm3(Predicted)
[storage temp. ] -15°C
[pka] 11.03±0.46(Predicted)

Hazard Information	Back Directory
[Uses] Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC50 value of 125 μM[1].
[References] [1] Moreira W, et, al. Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome. Front Microbiol. 2017 Apr 27;8:746. DOI:10.3389/fmicb.2017.00746

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