| Identification | Back Directory | [Name]
3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone | [CAS]
351986-85-1 | [Synonyms]
Vacuolin-1
Vacuolin-1 - CAS 351986-85-1 - Calbiochem
3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone
(E)-4-(2-(3-iodobenzylidene)hydrazinyl)-6-Morpholino-N,N-diphenyl-1,3,5-triazin-2-aMine
Benzaldehyde, 3-iodo-, 2-[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone
4-[(2E)-2-(3-iodobenzylidene)hydrazinyl]-6-(morpholin-4-yl)-N,N-diphenyl-1,3,5-triazin-2-amine | [Molecular Formula]
C26H24IN7O | [MDL Number]
MFCD00321410 | [MOL File]
351986-85-1.mol | [Molecular Weight]
577.42 |
| Chemical Properties | Back Directory | [Boiling point ]
719.7±70.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO:18.33(Max Conc. mg/mL);31.74(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.21(Max Conc. mM)
DMF:3.0(Max Conc. mg/mL);5.2(Max Conc. mM) | [form ]
White solid | [pka]
10.74±0.10(Predicted) | [color ]
White to off-white | [Appearance]
white powder | [InChIKey]
JMEJTSRAQUFNOP-TURZUDJPSA-N | [SMILES]
Ic1cc(ccc1)\C=N\Nc2nc(nc(n2)N(c5ccccc5)c4ccccc4)N3CCOCC3 |
| Hazard Information | Back Directory | [Description]
Vacuolin-1 is a triazine-based small chemical, a specific inhibitor of Ca2+–dependent lysosomal exocytosis. The inhibitor penetrates the cell, blocking the fusion of lysosomes with the plasma membrane. Vacuolin-1 does not affect other membrane-bound organelles and endocytic or secretory traffic. The inhibitor is widely used in studies on the release of lysosomal content and the modulation of autophagy. | [Uses]
Vacuolin-1 is a cell-permeable triazine that inhibits Ca2+-dependent fusion of lysosomes to the cell membrane inhibiting release of lysosomal content. | [Biological Activity]
Cell permeable: yes''Primary Target
Ca2+-dependent fusion of lysosomes with the plasma membrane''Product does not compete with ATP.''Reversible: no |
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| Company Name: |
Twochem Co.Ltd.
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| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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