| Identification | Back Directory | [Name]
6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | [CAS]
352554-02-0 | [Synonyms]
SIRT1-IN-1
6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
1H-Carbazole-1-carboxamide, 2,3,4,9-tetrahydro-6-methyl-
inhibit,Cytomegalovirus,CMV,antiviral,indole,Inhibitor,Sirtuin,SIRT1IN1,SIRT1 IN 1 | [Molecular Formula]
C14H16N2O | [MDL Number]
MFCD00846511 | [MOL File]
352554-02-0.mol | [Molecular Weight]
228.29 |
| Chemical Properties | Back Directory | [Boiling point ]
509.3±29.0 °C(Predicted) | [density ]
1.244±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
16.52±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM[1]. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity[2]. | [IC 50]
SIRT1: 0.205 μM (IC50); SIRT2: 11.5 μM (IC50); SIRT3: >100 μM (IC50) | [References]
[1] Andrew D Napper, et al. Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. DOI:10.1021/jm050522v
[2] Thomas Shenk, et al. Sirtuin Modulators as Inhibitors of Cytomegalovirus. US20160296523A1. |
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Biorbyt Ltd.
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