| Identification | Back Directory | [Name]
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester | [CAS]
3543-74-6 | [Synonyms]
Bendamustine USP RC C
Bendamustine Impurity 40
Bendamustine Dihydroxy Ester
Bendamustine Related Impurity 1
Bendamustine Related Compound C
5-[Bis(2-hydroxyethyl)amino]-1-meth
Bendamustine USP Related Compound C
ethyl 4-(5-(bis(2-hydroxyethyl)amino)
Bendamustine hydrochloride Intermediates 1
Bendamustine USP RC C /Bendamustine Impurity A
Bendamustin Impurity-A (USP related compound C)
[1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butano...
5-112-hydroxyethyl complex with -1-methyl-1H benzimizole-2-butyrate B chisel
5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-2-benziMidazolebutyric Acid Ethyl Ester
1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester
5-(bis(2-hydroxyethyl)amino)-1-methyl-1h-benzimidazole-2-butanoic acid ethyl est
Ethyl 4-(5-Bis(2-Hydroxy Ethyl)Amino-1-Methyl-1Hbenzo[D]Imidazole-2-Yl]Butanoate
ethyl 4-{5-[bis(2-hydroxyethyl)aMino]-1-Methyl-1H-1,3-benzodiazol-2-yl}butanoate
Ethyl-4-(5-(bis(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoate
Ethyl 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyrate
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
4-[5-[Bis(2-hydroxyethyl)aMino]-1-MethylbenziMidazol-2-yl]butanoic acid ethyl ester
1H-Benzimidazole-2-butanoicacid, 5-[bis(2-hydroxyethyl)amino]-1-methyl-, ethyl ester
4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acidethylester
[1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester Bendamustine Related | [EINECS(EC#)]
680-672-5 | [Molecular Formula]
C18H27N3O4 | [MDL Number]
MFCD09840918 | [MOL File]
3543-74-6.mol | [Molecular Weight]
349.42 |
| Chemical Properties | Back Directory | [Melting point ]
98-101°C | [Boiling point ]
580.6±50.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
14.26±0.10(Predicted) | [color ]
White to Brown |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Light Tan Solid | [Uses]
[1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester_x000D_Bendamustine Related Impurity 1 (cas# 3543-74-6) is a compound useful in organic synthesis. | [Synthesis]
Stir and dissolve 5-amino-1-methyl-1H-2-benzimidazole butyric acid ethyl ester (60g, 0.23mol), 600mL water, and 300mL glacial acetic acid in a 2L reaction flask, and cool to -50, Add 120 mL of ethylene oxide, and control the temperature to complete the reaction. Adjust the pH of the potassium carbonate solution to 7.0-7.3, extract with dichloromethane 300 mL×3, combine the organic phases, wash with purified water 200 mL×3, dry with anhydrous magnesium sulfate, filter, and concentrate to obtain a brown solid. Then add 1200 mL of ethyl acetate and heat to 70-80° C. to dissolve, cool to room temperature to crystallize, filter and dry to obtain 63 g of light brown solid 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester with a purity of 99.3%. The yield was 78.5%.
![5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester](/NewsImg/2024-03-27/6384713186339636192125883.png "5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester")
| [References]
[1] Patent: US2014/121383, 2014, A1. Location in patent: Paragraph 0094
[2] Patent: WO2012/176214, 2012, A2. Location in patent: Page/Page column 5 |
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