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357952-09-1

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357952-09-1 Structure

357952-09-1 Structure
IdentificationBack Directory
[Name]

STRESSCOPIN (3-40) (HUMAN) TRIFLUOROACETATE SALT
[CAS]

357952-09-1
[Synonyms]

UROCORTIN III HUMAN
STRESSCOPIN (3-40) (HUMAN)
Urocortin III human, ≥97% (HPLC)
STRESSCOPIN TRIFLUOROACETATE SALT HUMAN
FTLSLDVPTNIMNLLFNIAKAKNLRAQAAANAHLMAQI-NH2
UROCORTIN III (HUMAN) TRIFLUOROACETATE SALT
STRESSCOPIN (3-40) (HUMAN) TRIFLUOROACETATE SALT
PHE-THR-LEU-SER-LEU-ASP-VAL-PRO-THR-ASN-ILE-MET-ASN-LEU-LEU-PHE-ASN-ILE-ALA-LYS-ALA-LYS-ASN-LEU-ARG-ALA-GLN-ALA-ALA-ALA-ASN-ALA-HIS-LEU-MET-ALA-GLN-ILE-NH2
H-PHE-THR-LEU-SER-LEU-ASP-VAL-PRO-THR-ASN-ILE-MET-ASN-LEU-LEU-PHE-ASN-ILE-ALA-LYS-ALA-LYS-ASN-LEU-ARG-ALA-GLN-ALA-ALA-ALA-ASN-ALA-HIS-LEU-MET-ALA-GLN-ILE-NH2
THR-LYS-PHE-THR-LEU-SER-LEU-ASP-VAL-PRO-THR-ASN-ILE-MET-ASN-LEU-LEU-PHE-ASN-ILE-ALA-LYS-ALA-LYS-ASN-LEU-ARG-ALA-GLN-ALA-ALA-ALA-ASN-ALA-HIS-LEU-MET-ALA-GLN-ILE-NH2 TRIFLUOROACETATE SALT
[Molecular Formula]

C185H307N53O50S2
[MDL Number]

MFCD04041134
[MOL File]

357952-09-1.mol
[Molecular Weight]

4137.87
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[solubility ]

H2O: soluble
[form ]

solid
[Sequence]

Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Leu-Leu-Phe-Asn-Ile-Ala-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Gln-Ala-Ala-Ala-Asn-Ala-His-Leu-Met-Ala-Gln-Ile-NH2
Safety DataBack Directory
[Safety Statements ]

22-24/25
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) selectively binds to type 2 CRF receptors with Ki values of 13.5, 21.7, and >100 nM for mCRF2β, rCRF2α, and hCRF1, respectively. Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion[1][2].
[storage]

Store at -20°C
[References]

[1] Lewis K, et, al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7570-5. DOI:10.1073/pnas.121165198
[2] van der Meulen T, et, al. Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion. Nat Med. 2015 Jul;21(7):769-76. DOI:10.1038/nm.3872
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