| Identification | More | [Name]
2,3-Difluorophenylacetic acid | [CAS]
360-03-2 | [Synonyms]
2,2-DIFLUORO-2-PHENYLACETIC ACID
A,A-DIFLUOROPHENYLACETIC ACID
ALPHA,ALPHA-DIFLUOROPHENYLACETIC ACID
DIFLUORO(PHENYL)ACETIC ACID
alpha-Difluoro-benzeneacetic acid
2,3-DIFLUOROPHENYLACETIC ACID 95+%
2,3-Difluorophenylacetic acid
2,3-DIFLUUOROPHENYL ACETIC ACID
ɑ,ɑ-Difluorophenylacetic acid, 99% | [EINECS(EC#)]
623-610-4 | [Molecular Formula]
C8H6F2O2 | [MDL Number]
MFCD00498146 | [Molecular Weight]
172.13 | [MOL File]
360-03-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
65-75 °C | [Boiling point ]
0°C | [density ]
1.338±0.06 g/cm3(Predicted) | [Fp ]
0°C | [storage temp. ]
Refrigerator, Under inert atmosphere | [solubility ]
Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly) | [form ]
Solid | [pka]
1.04±0.10(Predicted) | [color ]
White to Pale Yellow | [InChI]
1S/C8H6F2O2/c9-8(10,7(11)12)6-4-2-1-3-5-6/h1-5H,(H,11,12) | [InChIKey]
PFKSLFZFBCIJOI-UHFFFAOYSA-N | [SMILES]
OC(=O)C(F)(F)c1ccccc1 | [CAS DataBase Reference]
360-03-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
C,Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
UN3261 | [WGK Germany ]
3 | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
2916399090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
α,α-Difluorophenylacetic acid is a phenylacetic acid with two fluorides on the benzylic carbon. The inductive effect of the difluoromethyl group increases the acidity of α,α-difluorophenylacetic acid. α,α-difluorophenylacetic acid and 2-arylbenzoimidazoles could be used as reaction substrates to synthesise difluoroarymethyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-ones through radical cascade cyclization[1]. | [Chemical Properties]
white to light yellow crystal powde | [Uses]
Α,α-Difluorophenylacetic acid is used as an intermediate in pharmaceuticals, pesticides, and liquid crystal materials. | [References]
[1] Kaixia Sui, Yuting Leng* and Yangjie Wu*. “Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones under Mild Conditions.” ACS Omega 8 8 (2023): 7517–7528.
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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