| Identification | Back Directory | [Name]
TLR2-IN-C29 | [CAS]
363600-92-4 | [Synonyms]
R2-IN-C29
TLR2-IN-C29
C29;C 29;C-29
Benzoic acid, 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl- | [Molecular Formula]
C16H15NO4 | [MOL File]
363600-92-4.mol | [Molecular Weight]
285.29 |
| Chemical Properties | Back Directory | [Melting point ]
>192°C (dec.) | [Boiling point ]
505.7±50.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.01±0.10(Predicted) | [color ]
Dark Orange | [Stability:]
Moisture Sensitive | [InChI]
InChI=1S/C16H15NO4/c1-10-12(16(19)20)6-4-7-13(10)17-9-11-5-3-8-14(21-2)15(11)18/h3-9,18H,1-2H3,(H,19,20) | [InChIKey]
WTGMGRFVBFDHGQ-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C1=CC=CC(N=CC2=CC=CC(OC)=C2O)=C1C |
| Hazard Information | Back Directory | [Uses]
TLR2-IN-29 is a inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. | [Biological Activity]
TLR2-IN-C29 is a toll/IL-1 receptor resistance (TIR) domain BB loop-targetingselective toll-like receptor 2 (TLR2) antagonist th at inhibits both human TLR2/1 and TLR2/6-mediated signaling (IC50 = 37.6/19.7 μM against 50 ng/mL Pam3CSK/Pam2CSK-induced reporter signalrespectivelyusing HEK293T TLR2/6 or TLR2/1 transfectants)while blocking only murine TLR2/1-but not murine TLR2/6-mediated signaling (1h 25-50 μM C29 treatment prior to 50 ng P3C/mL or 100 ng P2C/mL for 1h in murine macrophages)nor signaling induced by other TLR agonists and TNF-α. | [IC 50]
TLR2 |
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