| Identification | More | [Name]
4-Bromo-1-fluoro-2-nitrobenzene | [CAS]
364-73-8 | [Synonyms]
1-BROMO-4-FLUORO-3-NITROBENZENE
4-BROMO-1-FLUORO-2-NITROBENZENE
5-BROMO-2-FLUORONITROBENZENE
2-fluoro-5-bromonitrobenzene
5-Bromo-2-fluoronitrobenzene 98%
5-Bromo-2-fluoronitrobenzene98% | [EINECS(EC#)]
639-340-5 | [Molecular Formula]
C6H3BrFNO2 | [MDL Number]
MFCD00129165 | [Molecular Weight]
220 | [MOL File]
364-73-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear yellow to brownish liquid after melting | [Melting point ]
18-19 °C (lit.) | [Boiling point ]
240-241 °C (lit.) | [density ]
1.786 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.575(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Difficult to mix. | [form ]
Liquid After Melting | [color ]
Clear yellow to brownish | [BRN ]
2329084 | [InChI]
InChI=1S/C6H3BrFNO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H | [InChIKey]
UQEANKGXXSENNF-UHFFFAOYSA-N | [SMILES]
C1(F)=CC=C(Br)C=C1[N+]([O-])=O | [CAS DataBase Reference]
364-73-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Clear yellow to brownish liquid after melting | [Uses]
4-Bromo-1-fluoro-2-nitrobenzene is used in the synthesis of anti-inflammatory agents. | [Uses]
Used in the synthesis of anti-inflammatory agents.1 | [General Description]
4-Bromo-1-fluoro-2-nitrobenzene undergoes Sonogashira reaction with 2-fluoronitrobenzene to afford predominantly the bromo displacement product. | [Synthesis]
General procedure for the synthesis of 4-bromo-1-fluoro-2-nitrobenzene from 1-fluoro-2-nitrobenzene: After completion of the reaction, the reaction mixture was cooled to room temperature and slowly poured into ice water. The product 2-fluoro-5-bromonitrobenzene in the aqueous phase was extracted with 200 mL of ethyl acetate, and the organic phases were combined and concentrated under reduced pressure to give a brown solid crude product. The crude product was purified by recrystallization from petroleum ether and analyzed by gas chromatography (GC) with a purity of 98%, and 227.1 g of the pure product was obtained after drying with a yield of 40.0%. | [References]
[1] Journal of the American Chemical Society, 2004, vol. 126, # 48, p. 15770 - 15776
[2] Patent: CN104530107, 2016, B. Location in patent: Paragraph 0026 |
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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