| Identification | Back Directory | [Name]
PGP-4008 | [CAS]
365565-02-2 | [Synonyms]
Abcb1b
PGP-4008
PGP-4408
Mdr1b Rat
Mdr1b Rat Vesicular Transport Kit
rodent multidrug resistance protein
Recombinant Human p-Glycoprotein/MRP
N-(1-BENZYL-2,3-DIHYDRO-1H-PYRROLO[2,3-B]QUINOLIN-4-YL)-2-PHENYLACETAMIDE
Benzeneacetamide, N-[2,3-dihydro-1-(phenylmethyl)-1H-pyrrolo[2,3-b]quinolin-4-yl]- | [Molecular Formula]
C26H23N3O | [MDL Number]
MFCD03452998 | [MOL File]
365565-02-2.mol | [Molecular Weight]
393.48 |
| Hazard Information | Back Directory | [Description]
PGP-4008 is a selective inhibitor of P-glycoprotein (P-gp) that does not affect the activity of multidrug resistance-related protein 1 (MRP1). It is effective in vitro and, when delivered intraperitoneally, in vivo, inhibiting tumor growth when given with doxorubicin . PGP-4008 also enhances the ability of docetaxel to inhibit growth and drive apoptosis in ovarian cancer cells. | [Uses]
PGP-4008 is a specific P-glycoprotein (Pgp) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin[1]. | [storage]
Store at -20°C | [References]
[1] Brian D Lee, et al. Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11;47(6):1413-22. DOI:10.1021/jm0303204 |
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| Company Name: |
ZSGB-BIO
|
| Tel: |
02-400-810-9781 400810978 |
| Website: |
www.zsbio.com |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|