| Identification | More | [Name]
2,4-DINITRO-5-FLUOROANILINE | [CAS]
367-81-7 | [Synonyms]
2,4-DINITRO-5-FLUOROANILINE
5-FLUORO-2,4-DINITROANILINE
LABOTEST-BB LT00159531
2-4-DINITRO-5-FLUOROANILINE CRYSTALLINE
2 4-DINITRO-5-FLUOROANILINE 97%
2,4-Dinitro-5-fluoroaniline97%
2,4-DINITRO-5-FLUOROANILINE 98+%
Bergmanns Reagent, DNFA | [EINECS(EC#)]
206-700-4 | [Molecular Formula]
C6H4FN3O4 | [MDL Number]
MFCD00007150 | [Molecular Weight]
201.11 | [MOL File]
367-81-7.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,T | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
2811 | [WGK Germany ]
3
| [F ]
1-8-10 | [Hazard Note ]
Toxic | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29214200 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 5-fluoro-2,4-dinitroaniline from 1,5-difluoro-2,4-dinitrobenzene: 2.0 equivalents (1.02 mL) of ammonia were slowly added dropwise to a solution of 1.0 equivalents (4.0 mmol) of 1,5-difluoro-2,4-dinitrobenzene (DFDNB, 1) dissolved in 40 mL of THF under magnetic stirring. The reaction mixture was continued to be stirred at room temperature for 30 min. After removing the solvent by evaporation under reduced pressure, water was added to precipitate the product. The crude product 5-fluoro-2,4-dinitroaniline (2) was collected by filtration and washed well with water. The target product 5-fluoro-2,4-dinitroaniline was finally obtained in 99% yield and >99% purity by HPLC. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 14, p. 4189 - 4192
[2] Recueil des Travaux Chimiques des Pays-Bas, 1916, vol. 35, p. 142
[3] Chem. Zentralbl., 1913, vol. 84, # II, p. 760 |
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