| Identification | Back Directory | [Name]
Melphalan Flufenamide | [CAS]
380449-51-4 | [Synonyms]
Melflufen
Prodrug J-1
Melphalan Flufenamide
Prodrug J-1, Melflufen, Melphalan flufenamide | [Molecular Formula]
C24H30Cl2FN3O3 | [MDL Number]
MFCD32710101 | [MOL File]
380449-51-4.mol | [Molecular Weight]
498.42 |
| Hazard Information | Back Directory | [Uses]
Melflufen used in the treatment or prophylaxis of osteosarcoma. | [in vivo]
Melflufen (Melphalan flufenamide) (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model[1]. | Animal Model: | CB-17 SCID mice (human plasmacytoma MM.1S xenograft mouse model)[1] | | Dosage: | 3 mg/kg | | Administration: | I.v.; twice-weekly for two weeks | | Result: | Significantly inhibited MM tumor growth and prolonged survival of mice. |
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