| Identification | Back Directory | [Name]
NEUROPEPTIDE W-30 (RAT) | [CAS]
383415-90-5 | [Synonyms]
RL8C
NPW30 (RAT)
RPPL8 (42-71)
NEUROPEPTIDE W-30 (RAT)
PREPROPROTEIN L8 (42-71) (RAT)
Preproprotein L8 (42-71) (rat), rL8C, rPPL8 (42-71), NPW-30 (rat)
Neuropeptide W-30 (rat)
Preproprotein L8 (42-71) (rat), rL8C, rPPL8 (42-71), NPW-30 (rat)
TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-SER-GLY-LEU-LEU-MET-GLY-LEU-ARG-ARG-SER-PRO-TYR-LEU-TRP
H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-SER-GLY-LEU-LEU-MET-GLY-LEU-ARG-ARG-SER-PRO-TYR-LEU-TRP-OH | [Molecular Formula]
C165H249N49O38S1 | [MDL Number]
MFCD06412272 | [MOL File]
383415-90-5.mol | [Molecular Weight]
3559.11 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [form ]
solid
| [Sequence]
Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ser-Gly-Leu-Leu-Met-Gly-Leu-Arg-Arg-Ser-Pro-Tyr-Leu-Trp |
| Hazard Information | Back Directory | [Uses]
Neuropeptide W-30 (rat) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (rat) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. NPW-30 activates and binds to both GPR7 and GPR8 at similar effective doses[1][2][3]. | [References]
[1] Makoto Kawasaki, et al. Centrally administered neuropeptide W-30 activates magnocellular neurosecretory cells in the supraoptic and paraventricular nuclei with neurosecretion in rats. J Endocrinol. 2006 Aug;190(2):213-23. DOI:10.1677/joe.1.06636
[2] Nan-Shou Yu, et al. Effects of intracerebroventricular administration of neuropeptide W30 on neurons in the hypothalamic paraventricular nucleus in the conscious rat. Neurosci Lett. 2007 Mar 26;415(2):140-5. DOI:10.1016/j.neulet.2007.01.048
[3] Yukio Shimomura, et al. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. J Biol Chem. 2002 Sep 27;277(39):35826-32. DOI:10.1074/jbc.M205337200 |
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