| Identification | Back Directory | [Name]
(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | [CAS]
3862-25-7 | [Synonyms]
7HCO
alpha-HC
7α-hydroxycholestenone
7a-Hydroxy-cholestene-3-one
7-Hydroxy-4-cholesten-3-one
7a-Hydroxy-4-cholesten-3-one
7a-Hydroxycholest-4-en-3-one
(7a)-7-Hydroxycholest-4-en-3-one
7alpha-hydroxycholest-4-en-3-one
7 alpha-hydroxy-4-cholesten-3-one
(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-diMethyl-17-((R)-6-Methylheptan-2-yl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one | [Molecular Formula]
C27H44O2 | [MDL Number]
MFCD00870345 | [MOL File]
3862-25-7.mol | [Molecular Weight]
400.64 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
182-184°C | [Boiling point ]
516.7±29.0 °C(Predicted) | [density ]
1.03±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
14.49±0.70(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501). | [Definition]
ChEBI: A cholestanoid consisting of a cholesterol core having an oxo group at the 3-position, a C2C bond at the 4,5-position and an alpha-hydroxy group at the 7-position. | [Description]
7α-hydroxy-4-Cholesten-3-one is a metabolite of 7α-hydroxy cholesterol and an intermediate in the biosynthesis of bile acids. Plasma levels of 7α-hydroxy-4-cholesten-3-one positively correlate with the rate of bile acid synthesis in humans and are increased in patients following ileal resection. | [References]
[1] RUSSELL D W. The enzymes, regulation, and genetics of bile acid synthesis.[J]. Annual review of biochemistry, 2003, 72: 137-174. DOI: 10.1146/annurev.biochem.72.121801.161712
[2] M. AXELSON J. S A Aly. Levels of 7α-hydroxy-4-cholesten-3-one in plasma reflect rates of bile acid synthesis in man[J]. FEBS Letters, 1988, 239 2: Pages 324-328. DOI: 10.1016/0014-5793(88)80944-x |
| Spectrum Detail | Back Directory | [Spectrum Detail]
(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one(3862-25-7)1HNMR
|
|
|