| Identification | Back Directory | [Name]
KRX-0501 | [CAS]
393856-87-6 | [Synonyms]
KP 544
KRX-0501
XBVOXAWRUIZEMG-WKILWMFISA-N
Cyclohexanol, 4-[[2-aMino-5-[(4-chlorophenyl)ethynyl]-4-pyriMidinyl]aMino]-, trans- (9CI) | [Molecular Formula]
C18H19ClN4O | [MDL Number]
MFCD20526511 | [MOL File]
393856-87-6.mol | [Molecular Weight]
342.823 |
| Hazard Information | Back Directory | [Uses]
KP 544 is a potent neurotrophic protein enhancer that amplifies nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells and SH-SY5Y neuroblastoma cells. KP544 also enhances choline acetyltransferase activity. KP 544 selectively interact in the differentiation pathway downstream of MAPK in a manner that amplifies nerve growth factor and cyclic AMP effects and is also neuroprotective[1]. | [References]
[1] Fyfe J A, et al. KP544 amplifies the effects of nerve growth factor on cell differentiation and is neuroprotective[J]. Drug development research, 2004, 62(1): 49-59. |
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