| Identification | Back Directory | [Name]
PHA-680626 | [CAS]
398493-74-8 | [Synonyms]
PHA-680626
Benzamide, 4-(4-methyl-1-piperazinyl)-N-[1,4,5,6-tetrahydro-5-[2-(2-thienyl)acetyl]pyrrolo[3,4-c]pyrazol-3-yl]- | [Molecular Formula]
C23H26N6O2S | [MDL Number]
MFCD19689563 | [MOL File]
398493-74-8.mol | [Molecular Weight]
450.56 |
| Hazard Information | Back Directory | [Description]
PHA-680626 is a potent and selective PLK inhibitor. PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases. PHA-680626 inhibits Plk1 (IC50 = 0.53 μM), Plk2 (IC50 = 0.07 μM) and Plk3 (IC50 = 1.61 μM). |
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