| Identification | More | [Name]
2-Chloro-6-(trifluoromethyl)pyridine | [CAS]
39890-95-4 | [Synonyms]
2-CHLORO-6-(TRIFLUOROMETHYL)PYRIDINE
BUTTPARK 27\08-82
PYRIDINE, 2-CHLORO-6-(TRIFLUOROMETHYL)-
6-Chloro-2-(trifluoromethyl)pyridine
2-CHLORO-6-TRIFLUOROMETHYLPRIDINE
2-Chloro-5-trifluoromethylpyri
2-CHLORO-6-TRIFLUOROMETHYL-PYRIDINE >97% | [EINECS(EC#)]
624-440-3 | [Molecular Formula]
C6H3ClF3N | [MDL Number]
MFCD00042226 | [Molecular Weight]
181.54 | [MOL File]
39890-95-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to off-white liquid (or White to off-white crystal) | [Melting point ]
33 °C | [Boiling point ]
60-62°C 8mm | [density ]
1.416±0.06 g/cm3(Predicted) | [Fp ]
78°C | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [Water Solubility ]
Insoluble in water | [form ]
powder to lump | [pka]
-4.30±0.10(Predicted) | [color ]
White to Almost white | [FreezingPoint ]
32.0 to 34.0 ℃ | [BRN ]
4308910 | [InChI]
InChI=1S/C6H3ClF3N/c7-5-3-1-2-4(11-5)6(8,9)10/h1-3H | [InChIKey]
ADVQMCQMDHBTHJ-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC(C(F)(F)F)=CC=C1 | [CAS DataBase Reference]
39890-95-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T;Xn,Xi,Xn,T | [Risk Statements ]
R25:Toxic if swallowed.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
S9:Keep container in a well-ventilated place .
S36:Wear suitable protective clothing . | [RIDADR ]
2811 | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29333990 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Oral
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to off-white liquid (or White to off-white crystal) | [Uses]
2-Chloro-6-(trifluoromethyl)pyridine can be used in the synthesis of medicine, pesticide or biocidal product.
| [Chemical Reactivity]
2-Chloro-6-(trifluoromethyl)pyridine is stable under recommended storage conditions, it reacts with strong oxidizing agents, strong acids, strong bases. | [Synthesis]
General procedure for the synthesis of 2-chloro-6-trichloromethylpyridine from 2-chloro-6-trichloromethylpyridine: 2-chloro-6-trichloromethylpyridine (700 g, 3.03 mol, feed rate 1.24 g/min) and anhydrous hydrogen fluoride (936 g, 46.8 mol, feed rate 1.66 g/min) were added successively to a tubular reactor fitted with a preactivated chromium oxide-alumina catalyst (210 g) in a tubular reactor at a reaction temperature of 330 °C. The reaction products were cooled with ice water and collected. The reaction products were collected after cooling with ice water and extracted with dichloromethane. The extract was washed with 10% potassium hydroxide solution, and the organic layer was separated and concentrated to give 490.0 g of crude 2-chloro-6-trifluoromethylpyridine, which was analyzed by GC for 95.03% purity and 89% reaction yield. The crude product was purified by fractionation to obtain 2-chloro-6-trifluoromethylpyridine with 98.0% purity and 80.0% yield. | [References]
[1] Patent: WO2016/178248, 2016, A1. Location in patent: Page/Page column 5 |
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