| Identification | Back Directory | [Name]
NCX 1000 | [CAS]
401519-96-8 | [Synonyms]
NCX 1000
Cholan-24-oic acid, 3,7-dihydroxy-, 2-methoxy-4-[(1E)-3-[4-(nitrooxy)butoxy]-3-oxo-1-propen-1-yl]phenyl ester, (3α,5β,7β)- | [Molecular Formula]
C38H55NO10 | [MOL File]
401519-96-8.mol | [Molecular Weight]
685.84 |
| Chemical Properties | Back Directory | [Boiling point ]
758.3±60.0 °C(Predicted) | [density ]
1.198±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.79±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NCX 1000 is a liver-specific NO donor compound derived from ursodeoxycholic acid (UDCA). | [in vivo]
NCX-1000 (15 mg/kg, p.o.) prevents ascite formation, reduces collagen deposition in CCl4-treated rats. NCX-1000 administration almost completely reverts portal hypertension induced by CCl4, and reduces portal pressure in cirrhotic rats. NCX-1000 reverts HSC contraction induced by FCS, and also inhibits MCP-1 release from HSCs stimulated with TNF-α and IFN-γ[1]. NCX-1000 (28 mg/kg, p.o.) decreases portal pressure without affecting mean arterial pressure and heart rate in rats. NCX-1000 also reduces vasoconstriction by 60% caused by 30 μM NE in rats. Administration of NCX-1000 to BDL and sham operated rats results in a similar increase of nitrite/nitrate and cGMP concentrations in the liver[2]. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Fiorucci S, et al. NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8897-902. Epub 2001 Jul 10. DOI:10.1073/pnas.151136298
[2] Fiorucci S, et al. NCX-1000, a nitric oxide-releasing derivative of ursodeoxycholic acid, ameliorates portal hypertension and lowers norepinephrine-induced intrahepatic resistance in the isolated and perfused rat liver. J Hepatol. 2003 Dec;39(6):932-9. DOI:10.1016/s0168-8278(03)00393-3 |
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