401519-96-8

中文名称 401519-96-8

英文名称 NCX 1000

CAS 401519-96-8

分子式 C38H55NO10

分子量 685.84

MOL 文件 401519-96-8.mol

401519-96-8 结构式

基本信息物理化学性质 401519-96-8价格(试剂级) 常见问题列表

基本信息

中文别名

化合物 T19471

英文别名

NCX 1000
Cholan-24-oic acid, 3,7-dihydroxy-, 2-methoxy-4-[(1E)-3-[4-(nitrooxy)butoxy]-3-oxo-1-propen-1-yl]phenyl ester, (3α,5β,7β)-

物理化学性质

沸点758.3±60.0 °C(Predicted)

密度1.198±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)14.79±0.70(Predicted)

形态Solid

颜色White to off-white

401519-96-8价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/12/22	HY-U00023	401519-96-8 NCX 1000	401519-96-8	1 mg	2906元

常见问题列表

生物活性

NCX 1000 是一种肝特异性 NO 供体，它来源于熊去氧胆酸。

靶点

Human Endogenous Metabolite

体内研究

NCX-1000 (15 mg/kg, p.o.) prevents ascite formation, reduces collagen deposition in CCl4-treated rats. NCX-1000 administration almost completely reverts portal hypertension induced by CCl4, and reduces portal pressure in cirrhotic rats. NCX-1000 reverts HSC contraction induced by FCS, and also inhibits MCP-1 release from HSCs stimulated with TNF-α and IFN-γ. NCX-1000 (28 mg/kg, p.o.) decreases portal pressure without affecting mean arterial pressure and heart rate in rats. NCX-1000 also reduces vasoconstriction by 60% caused by 30 μM NE in rats. Administration of NCX-1000 to BDL and sham operated rats results in a similar increase of nitrite/nitrate and cGMP concentrations in the liver.