| Identification | Back Directory | [Name]
1-Bromoethyl acetate | [CAS]
40258-78-4 | [Synonyms]
1-BROMOETHYLACETATE
Cefuroxime Impurity 51
1-ACETOXY ETHYL BROMIDE
Theophylline Impurity 10
1-Bromoethyl acetate ,90%
1 - broMine ethyl acetate
1-Bromoethyl acetate[BEA]
(RS)-1-Acetoxyethyl BroMide
Ethanol, 1-bromo-, 1-acetate
1‐Acetoxy?Ethyl?Bromide?(1‐AEB)
1-Acetoxy Ethyl Bromide (1-AEB) CAS No. : 40258-78-4 | [EINECS(EC#)]
609-807-8 | [Molecular Formula]
C4H7BrO2 | [MDL Number]
MFCD08061392 | [MOL File]
40258-78-4.mol | [Molecular Weight]
167 |
| Chemical Properties | Back Directory | [Boiling point ]
122-125 °C(Press: 738 Torr) | [density ]
1.48 | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform (Sparingly), Methanol (Sparingly) | [form ]
Oil | [color ]
Colourless to Dark Brown | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C4H7BrO2/c1-3(5)7-4(2)6/h3H,1-2H3 | [InChIKey]
IIASCQBFNHWZBE-UHFFFAOYSA-N | [SMILES]
C(OC(=O)C)(Br)C |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Oil | [Uses]
1-Bromoethyl Acetate is a 1-haloalkyl ester that is used in the modification of of antibiotics. | [Synthesis]
1-bromoethyl acetate is prepared by reacting acetyl bromide and acetaldehyde using zinc chloride as a catalyst.
After cooling 30 ml of hydrogen bromide / acetic acid (1.2 equiv) to 0 ° C., 53.5 ml (1.0 equiv) of vinyl acetate was slowly added thereto, followed by stirring for 1 hour. It was extracted with dichloromethane, washed with distilled water at 0-5 ° C., dehydrated with anhydrous magnesium sulfate, and distilled under reduced pressure to obtain 81.4 g of 1-bromoethyl acetate.
 | [References]
[1] Patent: CN108383727, 2018, A. Location in patent: Paragraph 0052-0053; 0056-0057; 0061-0062; 0065-0074
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 16, p. 5915 - 5926 |
|
|