| Identification | Back Directory | [Name]
9-Octadecenamide, N-[(1S)-1-[[4-(phenylmethoxy)phenyl]methyl]-2-(phosphonooxy)ethyl]-, (9Z)- | [CAS]
403520-23-0 | [Synonyms]
VPC12249
VPC-12249
VPC 12249
9-Octadecenamide, N-[(1S)-1-[[4-(phenylmethoxy)phenyl]methyl]-2-(phosphonooxy)ethyl]-, (9Z)- | [Molecular Formula]
C34H52NO6P | [MOL File]
403520-23-0.mol | [Molecular Weight]
601.75 |
| Hazard Information | Back Directory | [Description]
VPC12249 is a lysophosphatidic acid receptor type 1 (LPA1) antagonist that plays a functional role in osteoclast differentiation and bone resorption activity. | [Uses]
VPC12249 is a competitive dual LPA1/LPA3 antagonist with Ki values of 137nM and 428 nM, respectively. VPC12249 inhibits calcium mobilization in HEK293T cells with a Ki value of ~130 nM. VPC12249 is promising for research of ovarian cancer and hypertensive diseases[1]. | [References]
[1] Heise CE, et al. Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist. Mol Pharmacol. 2001 Dec;60(6):1173-80. DOI:10.1124/mol.60.6.1173 |
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