| Identification | Back Directory | [Name]
5-BROMO-3-CYANO-2-HYDROXYPYRIDINE | [CAS]
405224-22-8 | [Synonyms]
5-bromo-2-hydroxynicotino...
5-Bromo-3-cyano-2(1H)-pyridinone
5-BROMO-3-CAYNO-2(1H)-PYRIDINONE
5-BROMO-2-HYDROXYNICOTINONITRILE
5-BROMO-3-CYANO-2-HYDROXYPYRIDINE
5-Bromo-2-hydroxynicotinonitrile98%
5-Bromo-2-hydroxynicotinonitrile 98%
5-Bromo-3-cyano-2-hydroxypyridine 98%
5-BROMO-2-HYDROXY-3-PYRIDINECARBONITRILE
5-bromo-2-hydroxypyridine-3-carbonitrile
5-bromo-2-oxo-1H-pyridine-3-carbonitrile
5-BroMo-2-oxo-2,3-dihydropyridine-3-carbonitrile
3-Pyridinecarbonitrile, 5-bromo-1,2-dihydro-2-oxo-
5-BROMO-3-CYANO-2-HYDROXYPYRIDINE ISO 9001：2015 REACH
5-Bromo-3-cyano-2-hydroxypyridine, 5-Bromo-2-hydroxypyridine-3-carbonitrile | [Molecular Formula]
C6H3BrN2O | [MDL Number]
MFCD07363806 | [MOL File]
405224-22-8.mol | [Molecular Weight]
199 |
| Chemical Properties | Back Directory | [Melting point ]
219-221 | [Boiling point ]
292.1±40.0 °C(Predicted) | [density ]
1.84±0.1 g/cm3(Predicted) | [storage temp. ]
Keep Cold | [form ]
solid | [pka]
6.87±0.10(Predicted) | [color ]
Beige | [InChI]
InChI=1S/C6H3BrN2O/c7-5-1-4(2-8)6(10)9-3-5/h1,3H,(H,9,10) | [InChIKey]
SWTLLSLCDHXNIU-UHFFFAOYSA-N | [SMILES]
C1(=O)NC=C(Br)C=C1C#N |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile from 2-oxo-1,2-dihydropyridine-3-carbonitrile: 2-oxo-1,2-dihydropyridine-3-carbonitrile (50 mg, 0.42 mmol) and sodium acetate (69 mg, 0.84 mmol) were dissolved in 5 mL of glacial acetic acid at room temperature, and stirred until complete dissolution. Subsequently, bromine (21.5 μL, 0.42 mmol) was slowly added to the solution and the reaction lasted for 2 hours. Upon completion of the reaction, the mixture was concentrated under vacuum to remove the acetic acid. The crude product was purified by column chromatography (using ethyl acetate as eluent) to afford 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile (69 mg, 75% yield) as a yellow solid. Melting point: 216~217°C. 1H NMR (400MHz, CD3COCD3): δ11.70 (s, 1H), 8.22 (d, J = 2.8Hz, 1H), 8.05 (d, J = 2.8Hz, 1H). | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 16, p. 3251 - 3255
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 23, p. 6578 - 6581
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 9, p. 1577 - 1580
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 20, p. 5578 - 5585
[5] Patent: US2004/19052, 2004, A1. Location in patent: Page/Page column 17 |
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