| Identification | Back Directory | [Name]
THIONICOTINAMIDE ADENINE DINUCLEOTIDE | [CAS]
4090-29-3 | [Synonyms]
THIO-NAD
Thio-NAD/S-NAD
THIONICOTINAMIDE-DPN
Thionicotinamide-NAD
Thionicotinamide-DPN oxidized form
THIONICOTINAMIDE ADENINE DINUCLEOTIDE
Thio-Nicotinamide Adenine Dinuclotide
Thino-Nicotinamide Adenine Dinuclotide
3-Thionicotinamide adenine dinucleotide
3-Thiocarbamoylpyridine adenine dinucleotide
Adenosine5'-(trihydrogen diphosphate), P'?
Thio-NAD Thionicotinamide adenine dinucleotide
Thionicotinamide Adenine Dinucleotide(THIO-NAD)
β-ThionicotinaMide adenine dinucleotide, Oxidized forM
β-Thionicotinamide adenine dinucleotide, 90%, Oxidized form
Thio-Nicotinamide-Adenine Dinucleotide, Oxidized (Thio-NAD).
beta-Thionicotinamide adenine dinucleotide, oxidised form 92+%
5'-ester with 3-(aMinothioxoMethyl)-1-b-D-ribofuranosylpyridiniuM, inner salt
ThionicotinaMide Adenine Dinucleotide oxidized forM [for BiocheMical Research] | [EINECS(EC#)]
223-828-6 | [Molecular Formula]
C21H27N7O13P2S | [MDL Number]
MFCD00079609 | [MOL File]
4090-29-3.mol | [Molecular Weight]
679.49 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
PBS (pH 7.2): 10 mg/ml | [form ]
powder to crystal | [color ]
Light orange to Yellow to Green | [InChIKey]
DQRRIGAXTAXHLR-NNYOXOHSSA-N | [SMILES]
O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OC[C@@H]2[C@H]([C@@H](O)[C@H]([N+]3=CC=CC(C(=S)N)=C3)O2)O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O |&1:1,2,3,15,16,17,19,32,r| | [CAS DataBase Reference]
4090-29-3 |
| Hazard Information | Back Directory | [Description]
Thionicotinamide adenine dinucleotide is an analog of NAD. Use of Thio-NAD instead of NAD as a substrate for NAD(+)-consuming enzymes is more advantageous since the reduced form of Thio-NAD exhibits a substantial increase in absorbance at 405 nM, the most commonly available wavelength on microplate readers. | [Chemical Properties]
Light yellow powder | [Uses]
Thionicotinamide adenine dinucleotide has been used as a substrate analog in S-adenosyl-l-homocysteine (AdoHcy) hydrolases (SAHH) inhibition assay and in NAD+ glycohydrolase activity. | [Application]
Thionicotinamide adenine dinucleotide (4090-29-3) is a NAD derivative used in the determination of Carnitine by an enzymic cycling method with carnitine dehydrogenase.
| [Biochem/physiol Actions]
Thionicotinamide adenine dinucleotide (sNAD) is an analog of coenzyme nicotinamide adenine dinucleotide (NAD) and NADH. sNAD is a potential inhibitor of NAD+ kinase. NAD+ kinase modulates NAD levels, contributing to cytotoxicity in cancer cells. | [storage]
Transport product sealed, dry, and protected from light at ambient temperature. Store product dry and protected from light. For long term storage keep below -20℃. | [References]
[1] SATOSHI WATABE. Ultrasensitive enzyme-linked immunosorbent assay (ELISA) of proteins by combination with the thio-NAD cycling method.[J]. Biophysics (Nagoya-shi, Japan), 2014, 10: 49-54. DOI: 10.2142/biophysics.10.49
[2] YUTA KYOSEI. Proposal of De Novo Antigen Test for COVID-19: Ultrasensitive Detection of Spike Proteins of SARS-CoV-2.[C]//10 8. 2020. DOI: 10.3390/diagnostics10080594
[3] WEN-HUNG WANG. A novel, rapid (within hours) culture-free diagnostic method for detecting live Mycobacterium tuberculosis with high sensitivity.[J]. EBioMedicine, 2020, 60: 103007. DOI: 10.1016/j.ebiom.2020.103007 |
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