| Identification | More | [Name]
1-Methylpiperidin-4-amine | [CAS]
41838-46-4 | [Synonyms]
1-(5-BROMOPYRIMIDIN-2-YL)[1,4]DIAZEPANE
4-Amino-1-methylpiperdine
1-Methyl-4-Amino Piperidine
4-AMINO-1-METHYLPIPERDINE, 98.5%
1-Methylpiperidin-4-amine
4-Amino-1-methylpiperidine
N-Methyl-4-aminopiperidine | [EINECS(EC#)]
628-217-1 | [Molecular Formula]
C6H14N2 | [MDL Number]
MFCD03426069 | [Molecular Weight]
114.19 | [MOL File]
41838-46-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
203-207 | [Boiling point ]
62-64°C 1mm | [density ]
0.91 | [refractive index ]
1.4700-1.4740 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
clear liquid | [pka]
9.92±0.20(Predicted) | [color ]
Colorless to Light orange to Yellow | [Detection Methods]
GC | [InChI]
InChI=1S/C6H14N2/c1-8-4-2-6(7)3-5-8/h6H,2-5,7H2,1H3 | [InChIKey]
ALOCUZOKRULSAA-UHFFFAOYSA-N | [SMILES]
N1(C)CCC(N)CC1 | [CAS DataBase Reference]
41838-46-4(CAS DataBase Reference) | [Storage Precautions]
Store under nitrogen |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2920 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅱ | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to yellow liquid | [Synthesis]
N-((4-methoxyphenyl)methyl)-4-amino-1-methylpiperidine (1 g, 4.27 mmol) was used as starting material, which was dissolved in a methanol solution of 4% formic acid (60 mL). Under argon protection, 10% Pd/C (1 g) was added to the reaction system and the reaction mixture was subsequently heated to reflux for 24 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was acidified with concentrated hydrochloric acid to a pH of about 1. The resulting solution was concentrated to give a yellow oily substance. The oily substance was purified by fast chromatography (eluent: methanol/dichloromethane = 3:7 with 3.5% ammonia) to give 249 mg (51% yield) of 4-amino-1-methylpiperidine (57-MBT36B) as a white solid. Thin layer chromatography (TLC) Rf value was 0.13 (unfolding agent: 10% dichloromethane solution in methanol with 3.5% ammonia). High performance liquid chromatography-mass spectrometry (HPLC-MS, Method B) showed the molecular ion peak MH+ = 115. ultraviolet/mass spectrometry (UV/MS) detection showed a percent purity of -/100. | [References]
[1] Patent: WO2007/124136, 2007, A1. Location in patent: Page/Page column 126-127 |
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