| Identification | Back Directory | [Name]
Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 3-(4-chlorophenyl)-5-(phenylmethyl)- | [CAS]
419547-73-2 | [Synonyms]
5-benzyl-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 3-(4-chlorophenyl)-5-(phenylmethyl)- | [Molecular Formula]
C19H14ClN3O | [MOL File]
419547-73-2.mol | [Molecular Weight]
335.79 |
| Chemical Properties | Back Directory | [Boiling point ]
538.2±60.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-1.76±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Transketolase-IN-4 is a potent transketolase inhibitor (IC50=3.9 μM). Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM[1][2]. | [References]
[1] Du MX, et al. Identification of novel small-molecule inhibitors for human transketolase by high-throughput screening with fluorescent intensity (FLINT) assay. J Biomol Screen. 2004 Aug;9(5):427-33. DOI:10.1177/1087057104263913
[2] Mao J, et al. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5320-3. DOI:10.1016/j.bmcl.2008.08.034 |
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