| Identification | More | [Name]
5-METHOXYFLAVONE | [CAS]
42079-78-7 | [Synonyms]
5-METHOXYFLAVONE
METHOXYFLAVONE, 5-
5-methoxy-2-phenyl-4-benzopyrone
5-Methoxyflavone,97%
5-Methoxy-2-phenyl-4H-1-benzopyran-4-one | [EINECS(EC#)]
255-652-0 | [Molecular Formula]
C16H12O3 | [MDL Number]
MFCD00016942 | [Molecular Weight]
252.26 | [MOL File]
42079-78-7.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
2932.99.7000 |
| Hazard Information | Back Directory | [Uses]
5-Methoxyflavone is a flavenoid and dietary derived inhibitor of cell proliferation. | [Definition]
ChEBI: 5-Methoxyflavone is an ether and a member of flavonoids. | [Biological Activity]
5-Methoxyflavone, a flavonoid, is an inhibitor of DNA polymerase-beta and a neuroprotectant against beta-amyloid toxicity. Possesses central nervous system sedative effect by regulating ionophilic GABAA receptors. | [in vitro]
5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. It (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF , 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 ( DR5) in a time-dependent manner. | [in vivo]
5-Methoxyflavone (100, 150 mg/kg, ip) significantly decreases the latency time to loss of righting reflex. It (50, 100 and 150 mg/kg, ip) exhibits a significant and dose decreases -dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, ip) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, ip) completely abolishesed the grooming response similar to diazepam treated animals. | [target]
| Target | Value | DNA polymerase β
() |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|