| Identification | Back Directory | [Name]
2-chloro-N-(2-(4-ethylphenyl)benzo[d]oxazol-5-yl)-5-nitrobenzamide | [CAS]
423150-91-8 | [Synonyms]
2-chloro-N-(2-(4-ethylphenyl)benzo[d]oxazol-5-yl)-5-nitrobenzamide | [Molecular Formula]
C22H16ClN3O4 | [MOL File]
423150-91-8.mol | [Molecular Weight]
421.84 |
| Hazard Information | Back Directory | [Description]
BAY4931 is a Potent Covalent PPARγ Inverse-Agonist. | [Uses]
BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM[1]. | [IC 50]
PPAR-γ: 0.17 nM (IC50, RT112-FABP4-NLucP cellular reporter assay); mouse PPARγ: 0.14 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay ); hPPARγ: 0.40 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay ) | [References]
[1] Orsi DL, et al. Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069. J Med Chem. 2022 Nov 10;65(21):14843-14863. DOI:10.1021/acs.jmedchem.2c01379 |
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