| Identification | Back Directory | [Name]
THP-PEG6-alcohol | [CAS]
42607-87-4 | [Synonyms]
THP-PEG7
42607-87-4
THP-PEG6-OH
CAS_42607-87-4
THP-PEG6-alcohol
3,6,9,12,15-Pentaoxaheptadecan-1-ol, 17-[(tetrahydro-2H-pyran-2-yl)oxy]- | [Molecular Formula]
C17H34O8 | [MDL Number]
MFCD26793752 | [MOL File]
42607-87-4.mol | [Molecular Weight]
366.45 |
| Chemical Properties | Back Directory | [Boiling point ]
469.0±45.0 °C(Predicted) | [density ]
1.10±0.1 g/cm3(Predicted) | [form ]
Liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
THP-PEG7 is a PEG linker containing a THP protecting group and a hydroxyl group. THP is acid labile and is commonly used for the protection of alcohol groups. The terminal hydroxyl group can be further reacted to derivatize the compound. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media. | [Uses]
THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. | [IC 50]
PEGs; Non-cleavable Linker | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
[2] Masahiro Tomita, et al. Antibody specifically recognizing resin plasticizer compound. WO2005105846A1. |
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