| Identification | More | [Name]
2-Amino-5-bromo-6-methylpyridine | [CAS]
42753-71-9 | [Synonyms]
2-AMINO-5-BROMO-6-METHYLPYRIDINE
2-AMINO-5-BROMO-6-PICOLINE
5-BROMO-6-METHYLPYRIDIN-2-AMINE
5-BROMO-6-METHYL-PYRIDIN-2-YLAMINE
6-AMINO-3-BROMO-2-METHYLPYRIDINE
6-AMINO-3-BROMO-2-PICOLINE
AKOS BBS-00004445
ASISCHEM W51193
BUTTPARK 43\57-95
TIMTEC-BB SBB000260
5-bromo-6-methyl-2-pyridinamin
2-AMINO-5-BROMO-6-METHYPYRIDINE
2-Amino-5-bromo-ALPHA-picoline
6-AMINO-3-BROMO-2-PICOLINE 98%
6-AMINO-3-BROMO-2-PICOLINE (6-AMINO-3-BROMO-2-METHYLPYRIDINE)
5-bromo-6-methylpyrdin-2-amine
5-fluoro-2-pyridin-2-amine
6-Amino-3-bromo-2-methylpyridine ,98%
2-Methyl-3-bromo-6-aminopyridine
5-Bromo-6-methyl-2-pyridinamine | [EINECS(EC#)]
255-927-5 | [Molecular Formula]
C6H7BrN2 | [MDL Number]
MFCD00068230 | [Molecular Weight]
187.04 | [MOL File]
42753-71-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow Cryst | [Melting point ]
79-84 °C(lit.)
| [Boiling point ]
234.3±35.0 °C(Predicted) | [density ]
1.5672 (rough estimate) | [refractive index ]
1.5500 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Fluffy Powder | [pka]
4.80±0.37(Predicted) | [color ]
White to off-white | [Sensitive ]
Hygroscopic | [Detection Methods]
HPLC,NMR | [BRN ]
114140 | [InChI]
InChI=1S/C6H7BrN2/c1-4-5(7)2-3-6(8)9-4/h2-3H,1H3,(H2,8,9) | [InChIKey]
SEOZHXRTVJPQPZ-UHFFFAOYSA-N | [SMILES]
C1(N)=NC(C)=C(Br)C=C1 | [CAS DataBase Reference]
42753-71-9(CAS DataBase Reference) | [EPA Substance Registry System]
42753-71-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
IRRITANT | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow Cryst | [Synthesis]
General steps: Example 2
Add 650 g of xylene as solvent to the reactor and heat to 115-120°C. The heating was continued under reflux conditions until the water was completely removed. The solvent was cooled to 70°C under nitrogen protection. Subsequently, 22 g of sodium amide was added and the solution was heated to 118-120 °C. Under reflux condition, 102 g of 2-bromo-3-methylpyridine was slowly added dropwise, and after completion of the dropwise addition, the reaction temperature was maintained at reflux for 1 hour. Upon completion of the reaction, the reaction solution was cooled to 45 °C. The reaction solution was then poured into ice water and the upper organic phase was separated. The xylene was concentrated under atmospheric pressure to 220 g remaining and cooled to 10-15 °C with stirring. After crystallization, 100 g of the target product 2-amino-5-bromo-6-methylpyridine was obtained with 99.3% purity and 90.1% yield. | [References]
[1] Patent: CN105348181, 2016, A. Location in patent: Paragraph 0023; 0024; 0025 |
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