| Identification | More | [Name]
2-Amino-5-bromo-6-methylpyridine | [CAS]
42753-71-9 | [Synonyms]
2-AMINO-5-BROMO-6-METHYLPYRIDINE
2-AMINO-5-BROMO-6-PICOLINE
5-BROMO-6-METHYLPYRIDIN-2-AMINE
5-BROMO-6-METHYL-PYRIDIN-2-YLAMINE
6-AMINO-3-BROMO-2-METHYLPYRIDINE
6-AMINO-3-BROMO-2-PICOLINE
AKOS BBS-00004445
ASISCHEM W51193
BUTTPARK 43\57-95
TIMTEC-BB SBB000260
5-bromo-6-methyl-2-pyridinamin
2-AMINO-5-BROMO-6-METHYPYRIDINE
2-Amino-5-bromo-ALPHA-picoline
6-AMINO-3-BROMO-2-PICOLINE 98%
6-AMINO-3-BROMO-2-PICOLINE (6-AMINO-3-BROMO-2-METHYLPYRIDINE)
5-bromo-6-methylpyrdin-2-amine
5-fluoro-2-pyridin-2-amine
6-Amino-3-bromo-2-methylpyridine ,98%
2-Methyl-3-bromo-6-aminopyridine
5-Bromo-6-methyl-2-pyridinamine | [EINECS(EC#)]
255-927-5 | [Molecular Formula]
C6H7BrN2 | [MDL Number]
MFCD00068230 | [Molecular Weight]
187.04 | [MOL File]
42753-71-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow Cryst | [Melting point ]
79-84 °C(lit.)
| [Boiling point ]
234.3±35.0 °C(Predicted) | [density ]
1.5672 (rough estimate) | [refractive index ]
1.5500 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Fluffy Powder | [pka]
4.80±0.37(Predicted) | [color ]
White to off-white | [Sensitive ]
Hygroscopic | [Detection Methods]
HPLC,NMR | [BRN ]
114140 | [InChI]
InChI=1S/C6H7BrN2/c1-4-5(7)2-3-6(8)9-4/h2-3H,1H3,(H2,8,9) | [InChIKey]
SEOZHXRTVJPQPZ-UHFFFAOYSA-N | [SMILES]
C1(N)=NC(C)=C(Br)C=C1 | [CAS DataBase Reference]
42753-71-9(CAS DataBase Reference) | [EPA Substance Registry System]
42753-71-9(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
IRRITANT | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow Cryst | [Synthesis]
General steps: Example 2
Add 650 g of xylene as solvent to the reactor and heat to 115-120°C. The heating was continued under reflux conditions until the water was completely removed. The solvent was cooled to 70°C under nitrogen protection. Subsequently, 22 g of sodium amide was added and the solution was heated to 118-120 °C. Under reflux condition, 102 g of 2-bromo-3-methylpyridine was slowly added dropwise, and after completion of the dropwise addition, the reaction temperature was maintained at reflux for 1 hour. Upon completion of the reaction, the reaction solution was cooled to 45 °C. The reaction solution was then poured into ice water and the upper organic phase was separated. The xylene was concentrated under atmospheric pressure to 220 g remaining and cooled to 10-15 °C with stirring. After crystallization, 100 g of the target product 2-amino-5-bromo-6-methylpyridine was obtained with 99.3% purity and 90.1% yield. | [References]
[1] Patent: CN105348181, 2016, A. Location in patent: Paragraph 0023; 0024; 0025 |
| Questions And Answer | Back Directory | [Application]
2-Amino-5-bromo-6-methylpyridine is an important chemical raw material or intermediate, widely used in the synthesis of pyridine drugs, and also has potential effects such as antibacterial, antidepressant, insecticidal, herbicidal, and antimicrobial properties. |
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