| Identification | Back Directory | [Name]
(4S)-4-hydroxy-L-proline hydrochloride | [CAS]
441067-49-8 | [Synonyms]
H-cis-Hyp-OH·HCl
(4S)-4-Hydroxy-L-Proline HCl
(4S)-4-hydroxy-L-proline hydrochloride
Cis-4-hydroxy-L-prolineMonohydrochloride
(2s,4S)-4-hydroxy-L-proline hydrochloride
L-Proline, 4-hydroxy-,hydrochloride, cis-
L-Proline, 4-hydroxy-, hydrochloride, (4S)-
(2S,4S)-cis-4-hydroxy-L-proline hydrochloride
L-Proline,4-hydroxy-,hydrochloride(1:1),(4S)-
(4S)-4-hydroxy-L-proline hydrochloride USP/EP/BP
cis-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C5H10ClNO3 | [MDL Number]
MFCD09953187 | [MOL File]
441067-49-8.mol | [Molecular Weight]
167.591 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Solid | [color ]
White to light yellow | [Optical Rotation]
-12.74°(C=1.01g/100mI, MEOH, 20°C, 589nm) |
| Hazard Information | Back Directory | [Uses]
cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | [IC 50]
Non-cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
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