| Identification | Back Directory | [Name]
FR 260330 dehydrate) | [CAS]
442198-67-6 | [Synonyms]
FK-330
ASP-9853
FR-260330
LS-192510
ASP 9853
(ASP9853
FR 260330 dehydrate)
2-Pyridinepropanamide, α-[[(2E)-3-(4-chlorophenyl)-1-oxo-2-propen-1-yl]amino]-N-[2-oxo-2-[4-[[6-(trifluoromethyl)-4-pyrimidinyl]oxy]-1-piperidinyl]ethyl]-, (αS)- | [Molecular Formula]
C29H28ClF3N6O4 | [MOL File]
442198-67-6.mol | [Molecular Weight]
617.03 |
| Hazard Information | Back Directory | [Uses]
FR260330 is a selective, orally active inhibitor for inducible nitric oxide synthase (iNOS) through suppression of iNOS dimerization. FR260330 inhibits the NO accumulation in rat splenocytes and human DLD-110 cells, with IC50 of 27 and 10 nM. FR260330 ameliorates the Lipopolysaccharides (HY-D1056)-induced inflammatory diseases in rats model[1]. | [IC 50]
iNOS | [References]
[1] Chida N, et al., Pharmacological profile of FR260330, a novel orally active inducible nitric oxide synthase inhibitor. Eur J Pharmacol. 2005 Feb 10;509(1):71-6. DOI:10.1016/j.ejphar.2004.12.028 |
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