| Identification | Back Directory | [Name]
Acetamide, 2-azido-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- | [CAS]
444287-85-8 | [Synonyms]
TNF-α-IN-8
Acetamide, 2-azido-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- | [Molecular Formula]
C15H12N6O5 | [MOL File]
444287-85-8.mol | [Molecular Weight]
356.3 |
| Hazard Information | Back Directory | [Uses]
TNF-α-IN-8 (compound I-42) is a TNF-α inhibitor. TNF-α-IN-8 is an isoindole-imide compound. TNF-α-IN-8 can be used for the research of cancer, heart disease, osteoporosis, inflammatory, allergic and autoimmune diseases[1]. TNF-α-IN-8 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [References]
[1] Robarge MJ, et al. ISOINDOLE-IMIDE COMPOUNDS, COMPOSITIONS, AND USES THEREOF. WO/2002/059106. 2002. |
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