| Identification | Back Directory | [Name]
DM1-SPP | [CAS]
452072-20-7 | [Synonyms]
DM1-SPP
SPP-DM1
Maytansine, N2'-deacetyl-N2'-[3-[[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-4-oxobutyl]dithio]-1-oxopropyl]- | [Molecular Formula]
C44H59ClN4O14S2 | [MDL Number]
MFCD28400101 | [MOL File]
452072-20-7.mol | [Molecular Weight]
967.54 |
| Hazard Information | Back Directory | [Uses]
SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP[1]. | [IC 50]
Maytansinoids | [References]
[1] Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules. DOI:10.1158/1535-7163.MCT-10-0644 |
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