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452072-20-7

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452072-20-7 Structure

452072-20-7 Structure
IdentificationBack Directory
[Name]

DM1-SPP
[CAS]

452072-20-7
[Synonyms]

DM1-SPP
SPP-DM1
Maytansine, N2'-deacetyl-N2'-[3-[[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-4-oxobutyl]dithio]-1-oxopropyl]-
[Molecular Formula]

C44H59ClN4O14S2
[MDL Number]

MFCD28400101
[MOL File]

452072-20-7.mol
[Molecular Weight]

967.54
Chemical PropertiesBack Directory
[density ]

1.39±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

9.82±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP[1].
[IC 50]

Maytansinoids
[References]

[1] Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules. DOI:10.1158/1535-7163.MCT-10-0644
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