| Identification | More | [Name]
3-FLUORO-DL-PHENYLALANINE | [CAS]
456-88-2 | [Synonyms]
2-AMINO-3-(3-FLUOROPHENYL)PROPIONIC ACID
3-FLUORO-DL-PHENYLALANINE
DL-3-FLUOROPHENYLALANINE
DL-M-FLUOROPHENYLALANINE
H-DL-PHE(3-F)-OH
H-M-FLUORO-DL-PHE-OH
M-FLUORO-DL-PHENYLALANINE
3-fluoro-3-phenylalanine
2-amino-3-(3-fluorophenyl)propanoic acid
DL-3-F-Phe-OH
3-(3-Fluorophenyl)-2-aminopropionic acid | [EINECS(EC#)]
207-272-1 | [Molecular Formula]
C9H10FNO2 | [MDL Number]
MFCD00004273 | [Molecular Weight]
183.18 | [MOL File]
456-88-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
~240 °C (dec.) | [Boiling point ]
305.0±32.0 °C(Predicted) | [density ]
1.1939 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
powder to crystal | [pka]
2.17±0.10(Predicted) | [color ]
White to Almost white | [BRN ]
2939807 | [CAS DataBase Reference]
456-88-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R37:Irritating to the respiratory system. | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
AY6300000 | [HS Code ]
2922498590 |
| Hazard Information | Back Directory | [Uses]
cell analysis
peptide synthesis | [Biological Activity]
m-Fluoro-DL-phenylalaninea toxic antimetaboliteis a racemic mixture of a substituted (halogenated) benzoyl D and L phenylalanine with potential use in antiviral and antimicrobial drug development. | [Synthesis]
General procedure for the synthesis of 3-fluoro-DL-phenylalanine from compound (CAS: 380-70-1): intermediate 231 (7.50 g, 21.43 mmol) was added to 94% hydrochloric acid (80 mL). The reaction mixture was stirred under reflux conditions for 15 h. The completion of the reaction was confirmed by TLC analysis. After completion of the reaction, the mixture was filtered to give white solid 233 in 86% yield. High resolution mass spectrometry (HRMS, ESI) analysis resulted in a calculated value of 184.0715 (M + H)+ for m/z, C9H10NO2 and a measured value of 184.0767. | [References]
[1] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1325 - 1344
[2] Journal of the American Chemical Society, 1950, vol. 72, p. 1806
[3] Organic Letters, 2018, vol. 20, # 19, p. 6298 - 6301 |
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